Nano-plastics —— Miscarriage [5.63]

Micro-/Nano-plastic exposure on placental health and adverse pregnancy risks: A novel assessment system based upon TRAEC strategy

Danyang Wan ^1,2,3, Yujie Liu ^2,3, Qianjing Chang ^2,3, Zhaofeng Liu ^2,3, Qing Wang ^2,3, Rui Niu ^2,3, Beibei Gao ^2,3, Quanquan Guan ^2,3,*and Yankai Xia ^1,2,3,*

Micro-/Nano-plastics (MNPs) detected in maternal and fetal placenta pose reproductive toxicity risks. Applying the TRAEC strategy, 40 studies on MNP toxicity to placenta scored 5.63, indicating moderate-low risk, possibly escalating with smaller particle size. Our experiments show high-dose 50 nm and 200 nm PS-NPs induce cell cycle arrest and apoptosis in placenta cells, disrupting mitochondrial function and causing reproductive toxicity. This study offers insights into MNPs' potential reproductive health impacts using TRAEC.

Article link: https://www.mdpi.com/2305-6304/12/8/553