PFASs —— Neurodevelopmental toxicity [5.61]

Effect of per- and polyfluoroalkyl substances on neurodevelopment: evidence-based risk assessment in the TRAEC strategy context

Jie Ning^#1,2,3, Chaoshun Ding^#2,3, Haoyi Xu^#4, Zhaofeng Liu^2,3, Quanquan Guan^2,3, Yankai Xia^1,2,3*, Qing Xu^4*

Maternal PFAS exposure may affect offspring neurodevelopment, but consensus is unclear. Using the TRAEC strategy, we analyzed 39 studies and found a mid-level risk score of 4.68. In vivo studies showed a higher risk score of 5.13. Four risk assessment tools validated our findings. In summary, maternal PFAS exposure poses a moderate risk for offspring neurodevelopmental disorders.